SciTechDaily
By Bar-Ilan University
June 7, 2026
A new study reveals that an extremely small change in a non-coding region of DNA can dramatically alter how sex develops in mice.
How much can a single letter of DNA matter? According to new research from Bar-Ilan University, one misplaced genetic “letter” can completely change the course of sexual development. In a study published in Nature Communications, researchers showed that adding just one DNA base to a regulatory region caused XX mice, which normally develop as females, to instead develop testes and male reproductive anatomy.
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